Vaginitis Research Today is a free monthly online journal that collates and summarizes the latest research about Vaginitis, including details on bacterial vaginitis, candida, symptoms, treatment,.

Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis.

Peixoto F, Camargos A, Duarte G, Linhares I, Bahamondes L, Petracco A

Laboratory of Human Reproduction, Teaching Hospital, Federal University of Minas Gerais, Brazil.

OBJECTIVE: To evaluate the efficacy and tolerability of a vaginal pessary containing 750 mg of metronidazole and 200 mg of miconazole nitrate used daily for 7 days in the treatment of vaginitis. METHODS: Ninety-two women with vaginitis participated in this phase 3 study using one vaginal pessary daily for 7 days. Gynecological and microbiological evaluations were carried out prior to and following treatment. RESULTS: Reductions occurred in symptoms and signs of vaginitis. Clinical cure rate was 87.7%, while the cure rates according to microscopy and Candida albicans culture were 81.8% and 73.9%, respectively. The cure rate for bacterial vaginosis was 75% and culture of Gardnerella vaginalis turned negative in 63.6% of cases following treatment. The medication was well tolerated. CONCLUSION: Use of a combination of 750 mg of metronidazole and 200 mg of miconazole in a single daily application was found to be effective in the treatment of the most common causes of vaginitis.

Published 7 July 2008 in Int J Gynaecol Obstet.
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